Preprint Finds AML CAR-T Activity Depends on Intact IFN-Gamma Signaling

Institution: University of Wisconsin-Madison · Mechanism: IFN-gamma Signaling in CAR-T Cytotoxicity · Application: Acute Myeloid Leukemia CAR-T · Stage: Preclinical · Date: August 31, 2026 Summary A non-peer-reviewed study reports that disrupting interferon-gamma signaling impaired anti-AML CAR-T function, unlike the dispensability previously observed in B-cell…