An online-first peer-reviewed Cancer Gene Therapy paper identifies surface ROR2 on a subset of adverse-risk AML, including stem-like cells, and reports selective killing with an anti-ROR2 CAR T construct. The central translational proposition is…
A peer-reviewed Leukemia paper published online October 9 connects direct leukemia–macrophage contact, tunneling nanotube transfer of AML mitochondria, and macrophage metabolic reprogramming to immune escape in pediatric AML. It is a compelling mechanistic signal…
Cullinan dosed the first participant in a planned potentially registrational Phase 2 study of CLN-049 in relapsed or refractory acute myeloid leukemia. The study uses a brief two-dose optimization phase followed by seamless transition…
A peer-reviewed pediatric AML study integrates paired diagnosis–relapse single-cell data with larger outcome cohorts to identify rare chemoresistant cell states that improve risk stratification and nominate drug vulnerabilities. The framework is translationally credible, but…
Ligand committed up to $47 million to AvenCell Therapeutics. Up to $41 million will be provided in exchange for mid-single-digit to low-double-digit royalties on worldwide sales across current and future AvenCell assets, and up…
Bristol Myers Squibb discontinued the Phase I program for ORM-6151, also known as BMS-986497, after reviewing clinical data in AML and MDS. The CD33-targeted degrader-antibody conjugate carried a GSPT1 molecular-glue payload and was the…
FDA issued a “study may proceed” notice for a Phase Ib study of TBS-2025, a VISTA-inhibiting monoclonal antibody, in relapsed or refractory acute myeloid leukemia with mutant NPM1 after failure of or relapse on…
A non-peer-reviewed study reports that disrupting interferon-gamma signaling impaired anti-AML CAR-T function, unlike the dispensability previously observed in B-cell acute lymphoblastic leukemia models. IFN-gamma increased AML-cell expression of CD123, Fas and ICAM-1 and strengthened…
A non-peer-reviewed study used CRISPR interference Perturb-seq to suppress 520 genes in primary mouse hematopoietic stem and progenitor cell cultures and resolve local transcriptional effects separately from shifts in cell-state abundance. The authors derived…
Researchers at Rice University and MD Anderson Cancer Center identified a class of PS127 compounds through a function-based cheminformatic screen that induce autophagy, disrupt redox homeostasis via glutathione reductase, and trigger apoptosis in acute…
