Preprint Finds AML CAR-T Activity Depends on Intact IFN-Gamma Signaling
A non-peer-reviewed study reports that disrupting interferon-gamma signaling impaired anti-AML CAR-T function, unlike the dispensability previously observed in B-cell acute lymphoblastic leukemia models. IFN-gamma increased AML-cell expression of CD123, Fas and ICAM-1 and strengthened…
