PTPN2 Deletion Sharpens CAR-T Activity and Exposes a Neurotoxicity Tradeoff

Institutions: Dana-Farber Cancer Institute / Boston Children’s Hospital · Edit: CRISPR PTPN2 Deletion · Model: Rhesus Macaque, Immunocompetent · Study Type: Peer-Reviewed (Blood Advances) · Date: September 3, 2026 Summary A Blood Advances study reports that CRISPR deletion of PTPN2 increased CAR-T signaling, proliferation, cytokine…