PTPN2 Deletion Sharpens CAR-T Activity and Exposes a Neurotoxicity Tradeoff
A Blood Advances study reports that CRISPR deletion of PTPN2 increased CAR-T signaling, proliferation, cytokine production, cytotoxicity and killing of low-antigen leukemia cells, but also increased central-nervous-system infiltration and immune-effector-cell-associated neurotoxicity in rhesus macaques….
