TP53 Allelic State Reprograms Human Blood Stem Cells, Study Finds

Consortium: Graz / EMBL Research Team · Finding: TP53 Allelic State Reprograms Human HSPCs · Publication: Leukemia · Date: August 18, 2026 Summary A peer-reviewed study used CRISPR/Cas9 and AAV6-mediated homology-directed repair to construct defined monoallelic and biallelic TP53 lesions in human cord-blood CD34+ hematopoietic…