TP53 Allelic State Reprograms Human Blood Stem Cells, Study Finds
A peer-reviewed study used CRISPR/Cas9 and AAV6-mediated homology-directed repair to construct defined monoallelic and biallelic TP53 lesions in human cord-blood CD34+ hematopoietic stem and progenitor cells. A single affected allele was sufficient to increase…
