University of Cambridge and Wellcome Sanger Institute researchers reported an immunocompetent, stepwise model of myeloid-neoplasm evolution. A patient-derived CEBPA N321D mutation created a long-lived premalignant state in Hoxb8-FL murine progenitors; every primary recipient developed…
A multi-institutional team led by Drexel University and the University of California, San Francisco reported CAR-engaging particles (CAREp), DNA-scaffolded PLGA microparticles that co-display a CAR-binding antigen and CD28 agonist. Repeated CAREp stimulation sustained expansion…
A Nature Biotechnology analysis applied six proteomic aging clocks to longitudinal serum samples from 42 participants in rentosertib’s randomized Phase IIa idiopathic pulmonary fibrosis trial. Treated groups generally shifted toward lower predicted biological age…
A peer-reviewed New England Journal of Medicine letter reports first-in-patient feasibility for a T-cell-targeted, non-replicating self-inactivating lentiviral vector that generates CD19 CAR-T cells directly in vivo. Sixteen patients with treatment-refractory neurologic autoimmune disease received…
A St. Jude longitudinal study detected tisagenlecleucel-derived CD19 CAR-T cells in cerebrospinal fluid in 28 of 29 pediatric and young-adult B-ALL patients at one month and in 41 of 49 later samples. CAR-T cells…
Researchers led by Helmholtz Munich and the Technical University of Munich built more than 100 synthetic transfer vehicles by combining natural RNA-packaging, membrane-binding and budding domains with AI-designed protein assemblies. The lead planar C8…
A peer-reviewed Nature Biotechnology study describes donor-complementary prime editing, or DoPE, for one-step targeted DNA insertion without a programmed double-strand break, recombinase or transposase. The system combined PE2*, paired overhang-complementary pegRNAs and double-stranded donors…
A Blood Advances study reports that CRISPR deletion of PTPN2 increased CAR-T signaling, proliferation, cytokine production, cytotoxicity and killing of low-antigen leukemia cells, but also increased central-nervous-system infiltration and immune-effector-cell-associated neurotoxicity in rhesus macaques….
A non-peer-reviewed study reports that disrupting interferon-gamma signaling impaired anti-AML CAR-T function, unlike the dispensability previously observed in B-cell acute lymphoblastic leukemia models. IFN-gamma increased AML-cell expression of CD123, Fas and ICAM-1 and strengthened…
A peer-reviewed Blood study used CRISPR/Cas9 to delete the endogenous Notch1 PEST domain in CD19-4-1BBζ CAR T cells, extending native Notch1 signaling without constitutive overexpression. Edited cells expanded more strongly after activation, increased in-vitro…
