A 39-patient prospective study from Qingdao University reported high remission and MRD-negativity rates with a fixed-dose inotuzumab ozogamicin regimen in newly diagnosed B-ALL. The results support further testing of an antibody-drug conjugate-centered frontline strategy,…
A retrospective comparison from Peking University People’s Hospital found that pairing olverembatinib with antibody-based immunotherapy produced encouraging response and survival signals as an alternative to transplantation in Ph+ ALL. The analysis supports further evaluation…
A same-day Leukemia study developed a transcriptome-derived molecular-age score for diffuse large B-cell lymphoma and linked age acceleration to progression within 24 months after R-CHOP. Across discovery and external cohorts, molecular age was more…
A July 26 British Journal of Cancer study linked elevated HDAC6 expression with relapse in pediatric and adult B-ALL cohorts and showed that pharmacologic inhibition or shRNA depletion reduced CXCL12-driven actin remodeling, endothelial migration,…
A peer-reviewed multicenter phase 3 study from China compared azacitidine plus chidamide and CHOP with CHOP alone in 128 previously untreated patients with peripheral T-cell lymphoma. The experimental regimen did not significantly improve overall…
A peer-reviewed Science Immunology study integrated whole-genome germline sequencing from more than 200 lymphoma patients treated with axicabtagene ciloleucel in ZUMA-1 and ZUMA-7 with clinical biomarkers and functional CAR-T experiments. Putatively deleterious STXBP2 variants…
The LEO CReWE study analyzed 1,504 patients with relapsed or refractory large B-cell lymphoma treated from 2002 through 2022. Although autologous transplantation or CAR-T was planned for 65% at second line, only 31% received…
A same-day peer-reviewed multicenter study followed 40 patients with POEMS syndrome treated at nine Catalan referral hospitals; 25 received first-line autologous stem-cell transplantation. After median follow-up of 94.2 months, five-year progression-free and overall survival…
A peer-reviewed Leukemia paper published online July 23 integrates cohort genomics with single-cell DNA sequencing to argue that recurrent disruption of transcriptional, chromatin, RNA-splicing, and cohesin regulators generally precedes whole-chromosome gains in acute myeloid…
Researchers introduced cellGeometry, a non-negative geometric deconvolution method that estimates cell-type composition in bulk RNA-sequencing samples using large single-cell reference atlases. The method was benchmarked on reference datasets containing more than three million cells…
