CALR Mutant MPNs Show a TIGIT Positive NK Cell State

Company Witalisz-Siepracka laboratory (academic) Event Type Peer-reviewed publication Modality Checkpoint (TIGIT) blockade hypothesis Asset Anti-TIGIT (preclinical, mouse model) Target TIGIT; CD112 Disease Area CALR-mutant myeloproliferative neoplasms (ET, myelofibrosis) Summary A peer-reviewed Leukemia paper published online November 3 reports preserved natural killer (NK) cell degranulation in…