Dual Gene Editing Improves CAR T Fitness in Preclinical Models

Company Zhou Lab (academic) Event Type Peer-reviewed publication (Nature) Modality CRISPR-edited CAR-T cells Asset NR4A1/SOCS3 double-knockout CAR-T Target NR4A1; SOCS3 Disease Area Solid and hematologic tumors (preclinical models) Summary A peer-reviewed Nature paper published online November 4 identifies concurrent NR4A1 and SOCS3 knockout as a…