Beam Therapeutics filed a federal complaint against former employee Zi Jun Wang, YolTech co-founder Yuxuan Wu, Shanghai-based YolTech and U.S.-based Serapha Bio, alleging misappropriation of base-editing delivery, payload and manufacturing know-how. The dispute centers…
Basecamp Research announced a $140 million oversubscribed Series C led by S32, with participation from NVIDIA and other investors. It plans to expand its EDEN biological foundation models and advance an in vivo cell…
A Wuhan University-led peer-reviewed study published online 11 September in Nature Biomedical Engineering reports nearly 70 percent prime editing of bulk mouse liver after one systemic lipid nanoparticle dose carrying prime editor RNA and…
A Nature paper published online September 16 describes “prime assembly,” a CRISPR-targeted dual-flap synthesis method for RNA-programmable integration of single- or double-stranded DNA without a nuclease-driven double-strand break or cell-cycle dependence. The platform recoded…
An AstraZeneca- and Integrated DNA Technologies-led Nature Communications study found that CRISPR-Cas9 off-target mutations and balanced translocations can differ across individual cells, differentiated cell types and mouse organs, even under the same guide and…
Precision BioSciences disclosed that the first participant received PBGENE-DMD in the Phase 1/2a FUNCTION-DMD trial. The program uses two ARCUS nucleases delivered in one AAV vector to excise DMD exons 45–55 and create an…
University of Wisconsin–Madison investigators used a genome-wide CRISPR screen to identify endogenous cellular barriers to nonviral genome editing. Among 19,114 genes, six high-confidence negative regulators improved editing across delivery formats, loci and payloads when…
