LNP Editing Preserves Stem Cell Yield in Sickle-Cell Models
A non-peer-reviewed study directly compared Cas9 ribonucleoprotein electroporation with lipid-nanoparticle delivery of Cas9 messenger RNA to disrupt the erythroid BCL11A enhancer in primary human hematopoietic stem and progenitor cells. Electroporation produced higher editing, while…
