RNA Editing Restores Alpha One Antitrypsin in Mouse Models

Company Korro Bio Event Type Preclinical data disclosure Modality GalNAc-conjugated ADAR-recruiting RNA editing oligonucleotide Asset KRRO-111 Target SERPINA1 mRNA (PiZ) Disease Area Alpha-1 antitrypsin deficiency Summary Korro disclosed striking mouse pharmacology for a redosable GalNAc RNA editor in alpha-1 antitrypsin deficiency. The dual functional-protein restoration…