PRMT5 Sustains Histone Supply During DNA Replication

Company Shechter laboratory and collaborators Event Type Peer-Reviewed Mechanistic Publication (Nature Communications) Modality Target biology (PRMT5 inhibition mechanism) Asset Not applicable (mechanistic study) Target PRMT5; histone H4 arginine 3 symmetric dimethylation Disease Area Oncology (PRMT5-inhibitor programs) Summary An online-first Nature Communications paper defines a PRMT5-dependent…