ASNS Links UBE3A Loss to Persistent Neuronal Stress in Angelman Syndrome

Company Washington University investigators Event Type Peer-Reviewed Preclinical Publication (Nature) Modality Target discovery (downstream pathway; genetic rescue in mice) Asset Not applicable (mechanism and target hypothesis) Target ASNS (asparagine synthetase); UBE3A substrate pathway Disease Area Angelman syndrome Summary A Nature paper identifies asparagine synthetase as…