MMP-Gated VSV Widens the Preclinical Window for Systemic Oncolytic Delivery

Company UConn Health; Mayo Clinic Event Type Peer-Reviewed Preclinical Publication (Signal Transduction and Targeted Therapy) Modality Oncolytic virus; MMP-gated vesicular stomatitis virus (IL-12-armed) Asset Pro-VSV-IN-IL12 (preclinical) Target Tumor-microenvironment matrix metalloproteinases (conditional activation of VSV-G) Disease Area Solid tumors (colorectal and breast cancer models) Summary A…