Notch1 Editing Enhances CAR T Expansion in Models

Company Massachusetts General Hospital / Mass General Brigham Event Type Preclinical Research Findings (Peer-Reviewed Publication) Modality CRISPR/Cas9 Gene-Edited CAR T-Cell Therapy Asset Notch1 PEST-Domain-Edited CD19-4-1BBζ CAR T Cells Target Endogenous Notch1 (CD19-directed CAR) Disease Area B-Cell Acute Lymphoblastic Leukemia (preclinical model) Summary A peer-reviewed Blood…