MARCH5 Complex Defines a Venetoclax-Sensitization Interface

Evidence Peer-reviewed publication · Discovery September 10, 2026 · Importance 4/5 · Direction Uncertain Summary A Blood study identified a stress-responsive complex formed by the mitochondrial E3 ligase MARCH5, UBE2J2 and MFN2 at mitochondria-endoplasmic-reticulum contact sites. Genetic loss of MARCH5 lowered the apoptotic threshold and…