A peer-reviewed, single-center study of 104 recipients of commercial CD19- or BCMA-directed CAR-T therapy found that overall clonal hematopoiesis was not associated with toxicity or survival. A small TP53-mutant CHIP subgroup, however, had worse…
TScan is cutting approximately 75% of its workforce, eliminating internal manufacturing and pausing further Phase III ALLOHA-2 enrollment because it lacks sufficient capital to complete the study. Resources will shift to preclinical in-vivo-engineered TCR-T…
Qi Biodesign researchers rationally engineered Bxb1 attachment-site DNA rather than only the integrase protein, identifying attB(V111) and related variants that increased large-cargo integration in human cells and plants. Combining engineered DNA and protein produced…
ArsenalBio is shifting its primary focus from clinical autologous solid-tumor cell therapies to in-vivo CAR-T programs spanning hematologic malignancies, autoimmunity and other chronic disease. The private company disclosed a substantial workforce reduction, retaining a…
Adicet disclosed FDA clearance of the ADI-212 IND for metastatic castration-resistant prostate cancer and unveiled an in-vivo CAR-T portfolio spanning multiple myeloma, non-Hodgkin lymphoma and solid tumors. ADI-212 is described as an off-the-shelf, gene-edited,…
A peer-reviewed preclinical study from Peking University collaborators and Antengene identified CD73 upregulation as a potential adaptive immune-suppression mechanism after selinexor exposure. In a syngeneic J558 myeloma model, the ATG-037 CD73 inhibitor plus ATG-010…
A non-peer-reviewed study directly compared Cas9 ribonucleoprotein electroporation with lipid-nanoparticle delivery of Cas9 messenger RNA to disrupt the erythroid BCL11A enhancer in primary human hematopoietic stem and progenitor cells. Electroporation produced higher editing, while…
A non-peer-reviewed study used CRISPR interference Perturb-seq to suppress 520 genes in primary mouse hematopoietic stem and progenitor cell cultures and resolve local transcriptional effects separately from shifts in cell-state abundance. The authors derived…
Seoul National University researchers published a prime-editing-derived DNA assembly system in Nature Biotechnology that enables kilobase-scale gene insertion and megabase-scale excision without generating double-strand breaks, demonstrating functional CD19 CAR-T cell engineering as a proof-of-concept…
Researchers at Rice University and MD Anderson Cancer Center identified a class of PS127 compounds through a function-based cheminformatic screen that induce autophagy, disrupt redox homeostasis via glutathione reductase, and trigger apoptosis in acute…
