TP53

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Suppressor tRNA Restores Nonsense Mutant p53 in Tumor Models

A peer reviewed Nature Communications paper published online 23 October 2026 reports lipid-nanoparticle-delivered suppressor tRNAs that read through premature TP53 stop codons, restore full-length p53, and shrink nonsense-mutant xenografts. This is preclinical proof of…

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October 23, 2026

Technology Modalities

TP53-Mutant CHIP Marks a High-Risk CAR-T Phenotype

A peer-reviewed, single-center study of 104 recipients of commercial CD19- or BCMA-directed CAR-T therapy found that overall clonal hematopoiesis was not associated with toxicity or survival. A small TP53-mutant CHIP subgroup, however, had worse…

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September 2, 2026

Suppressor tRNA Restores Nonsense Mutant p53 in Tumor Models

TP53-Mutant CHIP Marks a High-Risk CAR-T Phenotype

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