RNAi

ARO-MAPT Shows Deep CSF Tau Knockdown

Arrowhead reported interim Phase 1/2a data showing dose-dependent and durable cerebrospinal-fluid total-tau reductions after subcutaneous ARO-MAPT in healthy volunteers. Mean reduction at day 105 reached 73% at 12.8 mg/kg, with a maximum individual reduction…

Roche Licenses Rona ALK7 RNAi Program

Roche obtained an exclusive worldwide license to Rona Therapeutics’ investigational ALK7-targeting RNA interference program for obesity and metabolic disease. Rona is eligible for up to $100 million in combined upfront and near-term milestone payments,…