Niche-Mimetic Culture Expands Functional Long-Term HSCs
A peer-reviewed Blood study combined single-cell multiome profiling with a three-dimensional, N-cadherin-supported culture system, pharmacologic YTHDF2 inhibition and the self-renewal agonist UM729 to expand serially transplantable human long-term hematopoietic stem cells (LT-HSCs) with balanced…
