Summary Intellia Therapeutics reported that its in vivo CRISPR gene-editing therapy, lonvoguran ziclumeran (lonvo-z), met its Phase 3 primary endpoint in hereditary angioedema, reducing swelling attacks by 87% versus placebo and advancing toward FDA submission. What Happened Intellia announced positive…
Summary CorMedix reported positive Phase 3 results from the ReSPECT trial for rezafungin (REZZAYO), demonstrating non-inferiority to standard antimicrobial regimens for prevention of invasive fungal disease (IFD) in allogeneic hematopoietic stem cell transplant (allo-HSCT) patients. What Happened The Phase 3…
Summary Compass Therapeutics reported that its DLL4xVEGF-A bispecific antibody, tovecimig, failed to meet the overall survival (OS) endpoint in a Phase 2/3 trial in biliary tract cancer, despite showing a statistically significant progression-free survival (PFS) benefit. What Happened In the…
Summary Pfizer has discontinued a Phase 1 immunostimulatory drug-conjugate program in oncology, highlighting challenges in developing next-generation targeted delivery modalities. What Happened Pfizer ended development of an early-stage immunostimulatory drug-conjugate candidate that had been in Phase 1 testing. The program…
Summary Allogene Therapeutics announced it will present an interim futility analysis from its pivotal Phase 2 ALPHA3 trial of an allogeneic CAR-T therapy in first-line consolidation for large B-cell lymphoma (LBCL), with data expected on April 13, 2026. What Happened…
Summary Gilead Sciences has agreed to acquire German biotech Tubulis in a deal worth up to $5 billion, significantly expanding its antibody-drug conjugate (ADC) platform capabilities. The transaction underscores the strategic importance of ADC technologies in next-generation oncology pipelines. What…
Summary Astellas has declined to exercise its option on AviadoBio’s AAV-based gene therapy program targeting frontotemporal dementia (FTD), but the program will continue through nonprofit funding support. The development highlights an alternative pathway for sustaining high-risk, rare-disease programs despite pharmaceutical…
Summary The RNA therapeutics field is approaching a key inflection point with the anticipated initiation of the first clinical trial of engineered transfer RNA (tRNA) therapy, led by emerging players such as Alltrna. This modality targets nonsense mutations, representing a…
Summary Tempest Therapeutics reported its year-end 2025 business update, highlighting two key developments: the acquisition of dual-targeting CAR-T assets from Factor Bioscience and positive interim data from the ongoing REDEEM-1 Phase 1/2a trial of TPST-2003 in relapsed/refractory multiple myeloma. While…
